Prospection for aldose reductase inhibitors from SerpentinaDB

We have implemented a hypothesis driven prospection study of inhibitors of Aldose Reductase (AR), a potent target of diabetes, from R. serpentina PDMs and obtained two indole alkaloids as well as their structural analogs, as potential AR inhibitors. This study serves as a demonstration of utility of SerpentinaDB for rational search of therapeutic molecules and highlights its relevance.

Pathania S, Randhawa V, Bagler G (2013) Prospecting for Novel Plant-Derived Molecules of Rauvolfia serpentina as Inhibitors of Aldose Reductase, a Potent Drug Target for Diabetes and Its Complications. PLoS ONE 8(4): e61327.

Following are illustrations of prospection strategy implemented and plant-derived molecules that were identified.

Propsection strategy

Serpentina PDM leads